Injectable Hydrogel Based on Modified Gelatin and Sodium Alginate for Soft-Tissue Adhesive

Xing, Yuhang and Qing, Xueqin and Xia, Hao and Hao, Shiqi and Zhu, Haofang and He, Yiyan and Mao, Hongli and Gu, Zhongwei (2021) Injectable Hydrogel Based on Modified Gelatin and Sodium Alginate for Soft-Tissue Adhesive. Frontiers in Chemistry, 9. ISSN 2296-2646

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Abstract

To assist or replace the traditional suture techniques for wound closure, soft-tissue adhesives with excellent adhesion strength and favorable biocompatibility are of great significance in biomedical applications. In this study, an injectable hydrogel tissue adhesive containing adipic acid dihydrazide–modified gelatin (Gel-ADH) and oxidized sodium alginate (OSA) was developed. It was found that this tissue adhesive possessed a uniform structure, appropriate swelling ratio, good injectability, and excellent hemocompatibility and cytocompatibility. The adhesion capacity of the developed adhesive with optimized component and concentration was stronger than that of the commercial adhesive Porcine Fibrin Sealant Kit. All these results suggested that the developed hydrogel was a promising candidate for a soft-tissue adhesive.

Item Type: Article
Subjects: Scholar Eprints > Biological Science
Depositing User: Managing Editor
Date Deposited: 17 Mar 2023 05:09
Last Modified: 20 Sep 2024 04:40
URI: http://repository.stmscientificarchives.com/id/eprint/774

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