Progress in the Treatment of Henoch-Schonlein Purpura in Children

Henoch-Schonlein Purpura (HSP) is the most common leukocyte fragmentary vasculitis with IgA immune complex deposition in childhood, which may affect capillaries, arterioles and venules in various systems of the body. Henoch-Schonlein purpura nephritis (HSPN) can be diagnosed when kidney damage occurs in children with HSP, which is the most severe complication of HSP. However, if the treatment of children with HSPN is delayed or recurrent, more than 20% of these children eventually develop chronic renal failure, seriously affecting the prognosis and quality of life of the children. Therefore, early diagnosis and treatment are crucial to the prognosis of children with HSP. This article reviews the treatment of HSP and HSPN.