Nogueira, Diogo E.S. and Cabral, Joaquim M.S. and Rodrigues, Carlos A.V. (2021) Single-Use Bioreactors for Human Pluripotent and Adult Stem Cells: Towards Regenerative Medicine Applications. Bioengineering, 8 (5). p. 68. ISSN 2306-5354
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Abstract
Research on human stem cells, such as pluripotent stem cells and mesenchymal stromal cells, has shown much promise in their use for regenerative medicine approaches. However, their use in patients requires large-scale expansion systems while maintaining the quality of the cells. Due to their characteristics, bioreactors have been regarded as ideal platforms to harbour stem cell biomanufacturing at a large scale. Specifically, single-use bioreactors have been recommended by regulatory agencies due to reducing the risk of product contamination, and many different systems have already been developed. This review describes single-use bioreactor platforms which have been used for human stem cell expansion and differentiation, along with their comparison with reusable systems in the development of a stem cell bioprocess for clinical applications.
Item Type: | Article |
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Subjects: | Scholar Eprints > Engineering |
Depositing User: | Managing Editor |
Date Deposited: | 15 Dec 2022 10:59 |
Last Modified: | 07 Sep 2024 10:56 |
URI: | http://repository.stmscientificarchives.com/id/eprint/658 |