Hematopoietic Stem Cells: Nature and Niche Nurture

Brown, Geoffrey (2021) Hematopoietic Stem Cells: Nature and Niche Nurture. Bioengineering, 8 (5). p. 67. ISSN 2306-5354

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Abstract

Like all cells, hematopoietic stem cells (HSCs) and their offspring, the hematopoietic progenitor cells (HPCs), are highly sociable. Their capacity to interact with bone marrow niche cells and respond to environmental cytokines orchestrates the generation of the different types of blood and immune cells. The starting point for engineering hematopoiesis ex vivo is the nature of HSCs, and a longstanding premise is that they are a homogeneous population of cells. However, recent findings have shown that adult bone marrow HSCs are really a mixture of cells, with many having lineage affiliations. A second key consideration is: Do HSCs “choose” a lineage in a random and cell-intrinsic manner, or are they instructed by cytokines? Since their discovery, the hematopoietic cytokines have been viewed as survival and proliferation factors for lineage committed HPCs. Some are now known to also instruct cell lineage choice. These fundamental changes to our understanding of hematopoiesis are important for placing niche support in the right context and for fabricating an ex vivo environment to support HSC development.

Item Type: Article
Subjects: Scholar Eprints > Engineering
Depositing User: Managing Editor
Date Deposited: 03 Mar 2023 06:13
Last Modified: 07 Sep 2024 10:56
URI: http://repository.stmscientificarchives.com/id/eprint/657

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