Visible light-promoted transition metal-free direct C3-carbamoylation of 2H-Indazoles

Ma, Chunhua and Shang, Linchun and Zhao, Hanying and He, Xing and Lv, Qiyan and Zhang, Dandan and Jiang, Yuqin (2022) Visible light-promoted transition metal-free direct C3-carbamoylation of 2H-Indazoles. Frontiers in Chemistry, 10. ISSN 2296-2646

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Official URL: https://doi.org/10.3389/fchem.2022.1087834

Abstract

We reported a general transition metal-free transformation to access C3-carbamoylated 2H-indazoles via visible light-induced oxidative decarboxylation coupling, in the presence of oxamic acids as the coupling sources, 4CzIPN as the photocatalyst, and Cs2CO3 as the base. The great application potential of this mild condition is highlighted by the late-stage modification of drugs, N-terminal modification of peptides, and the good antitumor activity of the novel desired product.

Item Type:	Article
Subjects:	Scholar Eprints > Medical Science
Depositing User:	Managing Editor
Date Deposited:	10 Jan 2023 12:04
Last Modified:	07 Sep 2024 10:55
URI:	http://repository.stmscientificarchives.com/id/eprint/619

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