Mitochondrial Reactive Oxygen Species (ROS) Production Alters Sperm Quality

Chianese, Rosanna and Pierantoni, Riccardo (2021) Mitochondrial Reactive Oxygen Species (ROS) Production Alters Sperm Quality. Antioxidants, 10 (1). p. 92. ISSN 2076-3921

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Abstract

Besides ATP production, mitochondria are key organelles in several cellular functions, such as steroid hormone biosynthesis, calcium homoeostasis, intrinsic apoptotic pathway, and the generation of reactive oxygen species (ROS). Despite the loss of the majority of the cytoplasm occurring during spermiogenesis, mammalian sperm preserves a number of mitochondria that rearrange in a tubular structure at the level of the sperm flagellum midpiece. Although sperm mitochondria are destroyed inside the zygote, the integrity and the functionality of these organelles seem to be critical for fertilization and embryo development. The aim of this review was to discuss the impact of mitochondria-produced ROS at multiple levels in sperm: the genome, proteome, lipidome, epigenome. How diet, aging and environmental pollution may affect sperm quality and offspring health—by exacerbating oxidative stress—will be also described.

Item Type: Article
Subjects: Scholar Eprints > Agricultural and Food Science
Depositing User: Managing Editor
Date Deposited: 05 Jul 2023 03:59
Last Modified: 17 May 2024 11:17
URI: http://repository.stmscientificarchives.com/id/eprint/2213

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