Adsorption – Desorption and Theoretical Study of Propranolol Hydrochloride Drug on Chitosan and Cellulose Acetate Surfaces

The research is concerned with the study of adsorption of propranolol hydrochloride drug on the surface of chitosan and cellulose acetate polymers.

Adsorption isotherms of propranolol hydrochloride on the two surfaces used from aqueous solution were specified. These adsorption isotherms were seen to be in agreement with Freundlish adsorption isotherm. Temperature, pH, and ionic strength parameters were studied which affected the adsorption process of the drug and desorption of the drug from the surface was studied to determine the efficiency of the surfaces as drug carrier. Chitosan and cellulose acetate were used as a model adsorbent in the experiments. Hyperchem 8.08 program was conducted using semiempirical (PM3, AM1) method to compare between experimental and theoretical results, both results were pointed to cellulose acetate as better absorbent for the drug.