Electrochemical Biosensing Strategies to Detect Serum Glycobiomarkers

Changes in glycosylation profiles have emerged as indicators of diseases. Altered glycans and glycoproteins secreted by pathological tissues are found in human serum and are potential glycobiomarkers for early diagnostic and prognostic of diseases such as inflammation, infection and cancer. To obtain serum samples is a simple procedure and minimally invasive; thus the detection of glycobiomarkers in serum is attractive for clinical applications. Electrochemical biosensors are a friendly strategy for rapid, easy and highly sensitive measuring of glycans and glycoprotein biomarkers. The use of lectins as biorecognition elements in glycobiosensors has provided a specific detection and profiling of glycans linked to glycoproteins. Electrochemical glycobiosensors based on lectin interactions employed to characterize glycan profiles in serum glycoproteins constitute a promising tool in diagnostic and monitoring of diseases.